Compounds (phenyl / Ethinyl - (heteroaryl) - pyridin / / piridazin pyrimidin-2-yl) - acetamide, metabotropic glutamate receptor modulators； Preparation procedure； Pharmaceutical Composition and its use in schizophrenia, Cognitive diseases, Autism or Fragile X Syndrome

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专利权人:

F. HOFFMANN-LA ROCHE AG

发明人:

JAESCHKE, GEORG,LINDEMANN, LOTHAR,RICCI, ANTONIO,RUEHER, DANIEL,VIEIRA, ERIC,STADLER, HEINZ

申请号：

CL2014000818

公开号：

CL2014000818A1

申请日:

2014.04.03

申请国别(地区):

CL

年份:

2014

代理人:

摘要：

The present invention relates to ethynyl derivatives of formula I wherein U, V, W, Y, R, R1, R2, R3 and R3' are as described herein. It has been found that the compounds of general formula I are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).COMPUESTOS DERIVADOS DE (FENIL/HETEROARIL)-ETINIL-(PIRIDIN/PIRIMIDIN/PIRIDAZIN)-ACETAMIDA, MODULADORES DEL RECEPTOR METABOTROPICO DE GLUTAMATO mGLUR5； PROCEDIMIENTO DE PREPARACION； COMPOSICION FARMACEUTICA； Y SU USO EN ESQUIZOFRENIA, ENFERMEDADES COGNITIVAS, SINDROME X-FRAGIL O AUTISMO.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/