NEWTON, Gary Karl,STEWART, Mark Richard,PERRIOR, Trevor Robert,CROSBY, Stuart Richard,HOPKINS, Anna,NEGOITA-GIRAS, Gabriel,JENKINS, Kerry
申请号：
ES14706684
公开号：
ES2601086T3
申请日:
2014.02.21
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of general formula I: ** Formula ** where: one of V and W is N, and the other of V and W is C-H； R1 represents an aliphatic heterocyclyl group having 4, 5, 6, 7, 8, or 9 ring atoms, attached to the pyridyl group shown in formula I through a ring nitrogen atom, and optionally substituted with one or more substituents selected from halogen； OH； >； = OR NO2； CN； NRaRb； (CHRa) xCORc； O.CO.Rc； CO2Ra； CONHRd； (CHRa) xNRa.CORc； NRaCO2Rb； C (>； = NH) NH2； SO2Rc； NRaSO2Rc； CH (CF3) NH2； and groups C1-4alkyl, C1-4alkoxy, C1-4alkoxyC1-4alkyl, C2-4alkenyl and C2-4alkynyl, each optionally substituted with one or more substituents independently selected from halogen atoms, OH, S- alkyl, CONHRa and NRaRb groups； or R1 represents an NRa- (CHRa) x-C3-6 cycloalkyl group or a NRa- (CHRa) x-C3-6 heterocycloalkyl group, said heterocycloalkyl group containing a heteroatom, wherein the heteroatom is oxygen or nitrogen, and being said cycloalkyl or heterocycloalkyl optionally substituted with one or more substituents selected from halogen； OH； >； = OR NO2； CN； NRaRb； (CHRa) xCORc； O.CO.Rc； CO2Ra； CONHRd； (CHRa) xNRa.CORc； NRaCO2Rb； C (>； = NH) NH2； SO2Rc； NRaSO2Rc； CH (CF3) NH2； and groups C1-4alkyl, C1-4alkoxy, C1-4alkoxyC1-4alkyl, C2-4alkenyl and C2-4alkynyl, each optionally substituted with one or more substituents independently selected from halogen atoms, OH, S groups -alkyl, CONHRa and NRaRb； or R1 represents NRa-C1-6alkyl optionally substituted with one or more substituents independently selected from halogen； OH； >； = OR NO2； CN； NRaRb； (CHRa) xCORc； O.CO.Rc； CO2Ra； CONHRd； (CHRa) xNRa.CORc； NRaCO2Rb； C (>； = NH) NH2； SO2Rc； NRaSO2Rc； CH (CF3) NH2； and groups C1-4alkyl, C1-4alkoxy, C1-4alkoxyC1-4alkyl, C2-4alkenyl and C2-4alkynyl, each optionally substituted with one or more substituents independently selected from halogen atoms, OH, S groups -alkyl, CONHRa and NRaRb； x is 0, 1 or 2； R2 represents ** Formula ** in which A is a phenyl or a 5- to 10-membered he
