HIGUCHI ROBERT I.,ROBERTS TUCKER CURRAN,SMITH PETER ANDREW,CAMPBELL DAVID,DURON SERGIO G.
申请号：
ARP120101877
公开号：
AR086585A1
申请日:
2012.05.28
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
Antibacterial compounds with a wide range of biological activities, in some forms of execution. In other forms of implementation, they can overcome single amino acid mutations in bacterial cucumber signaling (SPASA) and other forms of PRCompared with natural products, they have a wider range of antibiotic activities. A pharmaceutical composition and a treatment method for using compound 1 are also provided: a formula compound (1), wherein E1 and E2 are independent compounds between C1-6 tar.2. Alquenilo c2-7, tar c2-7, cycloquilo c3-7, isoacrylonitrile, isopropene, isopropene, or arilo, L1 is a combination, or- yes.-NR4...-C (O) --CH2O...- er...-CH2S...-Sch2...-CH2N4...-NR4CH2...-NR4C (O) -,-C (O) NR4-,-NR4S (O) 2--S (O) 2NR4--NR4C (O) NR4--NR4C (O) O--OC (O) NR4-O selectively replace C1-4 tar with Oh, CN, NO2, halogen, C1-6 tar； L2 is a combination or selective replacement of C1-6 tar； X is C (o) R20, s (o) 2r20, or C (o) nr21ac (r22a) (r23a) B (R24) 2, wherein r21a, r22a, r23a are hydrogen, C1-6 tar, c3-7, heterosexual and heterosexual respectively. 5 to 7 members of isopropene, or arilo C6-10, of which at least one r21a, r22a, r23a is not hydrogen, and any tar, cyclopropene, isopropene, arilo or isopropene can be replaced by 1 to 3j； R24 is h or C1-6 tar； R20 is optional alternative tar, optional alternative alternative alcox, or nr20ar20b,Where r20a is h, alternative asphalt, or SO2 asphalt C1-6； r20b is h, alternative asphalt； or X is a set of formula (2) or (3),N4, N5, and N6 are 1, 2, or 3 respectively； N7 is 0, 1, or 2； r21b and r22b are hydrogen, hydrogen Xi, C1-6 tar, cycloquilo c3-7, isopropene of 5 to 7 members, isopropene of 5 to 7 members, or arilo C6-10, which contains any asphalt, cyclopropene, isopropene, isopropene, isopropene, Arilo or heterosexual was replaced by 1-3 J； R25 was h, O H, ORC, a residual formulation group (4),Hexafluoro 1, hexaoxy (or hexaoxy (or hexa) to hexaoxy (or hexa (or) 18) one fluorine (or one fluorine (or) 18) (2) 1.5 to 7
