LONG JIANG,OR YAT SUN,MA JUN,WANG GUOQIANG,WANG BIN
申请号：
ARP110103420
公开号：
AR083052A1
申请日:
2011.09.20
申请国别(地区):
AR
年份:
2013
代理人:
摘要：
These compounds inhibit the activity of SERINA protein, especially the ns3-n4a proteome of hepatitis C virus (VHC). Therefore, the compounds in this application interfere with the life cycle of hepatitis C virus and can also be used as anti-virus agents. 1. Pharmaceutical compound containing the above compound taken by a person infected with VHC 1: a compound characterized by formula (1), wherein a is zero, - (C = O),-S (O) 2 -C (3DN-OR1) - o -C (3DN-CN) -B from the replacement c3-12 cyclopentanediol, c3-12 cyclopentanediol, the replacement c3-12 cyclopentanediol, the replacement c3-12 cyclopentanediol, the replacement c3-12 cyclopentadienyl isocyclopentadiene and the replacement c3-12 cyclopentadienyl isocyclopentadiene； or B is the remaining preparation (2),Among them, R7 and R8 are c1-8 tar or C2-8 alquenilo C8, which can be replaced by one or more halogens； M1 and M2 are independently selected from each other or N1； each R1 is a separate category: (I) hydrogen； (II) arilo； alternative arilo； heteromorphic arilo； alternative isopropene； alternative isopropene； and (IV) c1-8 tar, C2-8 pixel, C2-8 tar, each containing 0, 1, 2, or 3 heteroatoms selected from O, s, or N； alternative c1-8 tar, alternative alquenio C2-8,Or replace C2-8 tar, each containing 0, 1, 2 or 3 heteroatoms selected from O, s or N； replaced c3-12 cyclododecane； replaced c3-12 cyclododecane or c3-12 cyclododecane； independently select L1 and L2 from c1-8 tar and C2-8 cyclododecane, Or C2-8 tar, each containing 0, 1, 2 or 3 heteroatoms selected from O, s, or N； c1-8 replacing tar, C2-8 replacing ivory； or C2-8 replacing tar, each containing 0, 1, 2 or 3 heteroatoms selected from O, s, or N； cycloquileno c3-12, Or replace c3-12 ring 12, each containing 0, 1,2 or 3 heteroatoms selected from O, s or N, and c3-12 and c3-12, each containing 0, 1, 2 or 3 heteroatoms selected from O, s or n. W is empty, O- yes.- en...-No (me)-C (o) NH-This is life. This is life.X and carbon atoms combine to form a cycle
