DIMOPOULOS PASCHALIS,HALL ADRIAN,KITA YOICHI,MADIN ANDREW,SHUKER NICOLA LOUISE
申请号：
IN5529/DELNP/2013
公开号：
IN2013DN05529A
申请日:
2013.06.20
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
The present invention relates to a fused aminodihydrothiazine derivative of formula (I): wherein R is hydrogen or C alkyl optionally substituted by one to five halogen atoms n is 0 1 2 or 3 Ar is phenyl or a 5 or 6 membered heteroaromatic group containing 1 2 or 3 N atoms which Ar is optionally substituted by one to three substituents selected from hal hydroxyl CN Calkyl Calkenyl Calkynyl alkoxy Ccycloalkoxy and pyrazine where Calkyl and Calkoxy are optionally substituted by one to three halogen atoms and pharmaceutically acceptable salts thereof which compound has an Aß production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease1 caused by Aß and typified by Alzheimer type dementia.
