ONEILL, JAMES, DENNEN,ОНил Джеймс Деннен,BAMAT, MICHAEL, K.,Беймат Майкл К.,VON BORSTEL, REID, W.,фон Борштель Рид У.,SHARMA, SHALINI,Шарма Шалини,ARUDCHANDRAN, RAMACHANDRAN,Арудчандран Рамачандран
申请号：
UA2010012059
公开号：
UA103894C2
申请日:
2009.03.13
申请国别(地区):
UA
年份:
2013
代理人:
摘要：
Uric acid in mammalian subjects is reduced and excretion of uric acid is increased by administering a compound of Formula (I) or a pharmaceutically acceptable salt thereof. In Formula (I) m is 0, 1, 2, 3 or 4 n is 0 or 1 m + n is not more than 4 t is 0 or 1 q is 0 or 1 and r is 0, 1 or 2. Ris hydrogen, methyl or ethyl and Ris hydrogen or methyl, or Ris hydroxy and Ris hydrogen, or Ris O and Ris absent, or Rand Rtogether are -CHCH-. Ris hydrogen or alkyl having from 1 to 3 carbon atoms. One of Rand Ris alkyl having from 1 to 3 carbon atoms, and the other is hydrogen or alkyl having from 1 to 3 carbon atoms. Ris hydrogen, halo, alkyl having from 1 to 3 carbon atoms or alkoxy having from 1 to 3 carbon atoms. X is C(O) and r is 0 and t is 0 or X is NH(R) wherein Ris hydrogen or alkyl having from 1 to 3 carbon atoms. A is phenyl, unsubstituted or substituted by 1 or 2 groups selected from halo, hydroxy, methyl, ethyl, perfluoromethyl, methoxy, ethoxy, and perfluoromethoxy or a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compound of Formula (I) by a ring carbon or cycloalkyl having from 3 to 6 ring carbon atoms wherein the cycloalkyl is unsubstituted or one or two ring carbons are independently monosubstituted by methyl or ethyl. The uric acid-lowering effects of the Compounds of Formula (I) are used to treat or prevent a variety of conditions including gout, hyperuricemia, elevated levels of uric acid that do not meet the levels customarily justifying a diagnosis of hyperuricemia, renal dysfunction, kidney stones, cardiovascular disease, risk for developing cardiovascular disease, tumor-lysis syndrome, and cognitive impairment.Винахід стосується способу зниження рівнів сечової кислоти в організмах ссавців та посилення виділення сечової кислоти за рахунок введення в організм сполуки Формули І або фармацевтично прийнятної солі цієї сполуки.(I)у Формулі І
