EMIL D. KAKKIS,PAUL A. FITZPATRICK,MICHEL C. VELLARD,DANIEL J. WENDT,MUBARACK MUTHALIF,SEAN M. BELL,AUGUSTUS, O. OKHAMAFE
申请号：
PT08795357
公开号：
PT2175875T
申请日:
2008.08.15
申请国别(地区):
PT
年份:
2016
代理人:
摘要：
The present invention is directed to phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. The invention provides compositions of prokaryotic PAL and biologically active fragments, mutants, variants or analogs thereof, as well as methods for the production, purification, and use of such compositions for therapeutic purposes, including the treatment of cancer.
