VELLARD Michel C.,VELLARD Michel C.,FITZPATRICK Paul A.,FITZPATRICK Paul A.,KAKKIS Emil D.,KAKKIS Emil D.,WENDT Daniel J.,WENDT Daniel J.,MUTHALIF Mubarack,MUTHALIF Mubarack,BELL Sean M.,BELL Sean M.
申请号：
SI200831703
公开号：
SI2175875T1
申请日:
2008.08.15
申请国别(地区):
SI
年份:
2017
代理人:
摘要：
The present invention is directed to phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. The invention provides compositions of prokaryotic PAL and biologically active fragments, mutants, variants or analogs thereof, as well as methods for the production, purification, and use of such compositions for therapeutic purposes, including the treatment of cancer.
