VELLARD, MICHEL C.,FITZPATRICK, PAUL A.,KAKKIS, EMIL D.,WENDT, DANIEL J.
申请号：
MYPI 20094868
公开号：
MY151413A
申请日:
2008.05.23
申请国别(地区):
MY
年份:
2014
代理人:
摘要：
THE PRESENT INVENTION IS DIRECTED TO PHENYLALANINE AMMONIA-LYASE (PAL) PRODUCED BY PROKARYOTES, WHEREIN SUCH PROKARYOTIC PAL WHEREIN THE PAL VARIANT HAS A GREATER PHENYLALANINE-CONVERTING ACTIVITY AND/OR A REDUCED IMMUNOGENICITY AS COMPARED TO A WILD-TYPE PAL. THE INVENTION THUS PROVIDES COMPOSITION OF BACTERIAL PAL AND BIOLOGICALLY ACTIVE FRAGMENTS, MUTANTS, VARIANTS AND ANALOGS THEREOF, AS WELL AS METHODS FOR THE PRODUCTION, PURIFICATION, AND USE OF SUCH COMPOSITIONS FOR THERAPEUTIC AND INDUSTRIAL PURPOSES. FIG 1A
