compositions \u043f\u0440\u043e\u043a\u0430\u0440\u0438\u043e\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0439 phenylalanine ammonia - lyase, and patterns of use of these compositions
the present invention is directed to phenylalanine - ammonia - \u043b\u0438\u0430\u0437\u0443 (pal), \u043f\u0440\u043e\u0434\u0443\u0446\u0438\u0440\u0443\u0435\u043c\u0443\u044e \u043f\u0440\u043e\u043a\u0430\u0440\u0438\u043e\u0442\u0430\u043c\u0438 where such \u043f\u0440\u043e\u043a\u0430\u0440\u0438\u043e\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f pal is a kind ofwhere has higher \u0444\u0435\u043d\u0438\u043b\u0430\u043b\u0430\u043d\u0438\u043d\u043f\u0440\u0435\u0432\u0440\u0430\u0449\u0430\u044e\u0449\u0443\u044e version of pal activity and \/ or a reduced immunogenicity compared with pal wild type.the present invention therefore provides compositions of bacterial pal and its biologically active fragments, mutants, variants and analogues, as well as \u0441\u043f\u043e\u0441 both receivepurification and use of such compositions for therapeutic and industrial purposes.
