VELLARD MICHEL C U S A,FITZPATRICK PAUL A U S A,KAKKIS EMIL D U S A,WENDT DANIEL J U S A,MUTHALIF MUBARACK U S A,BELL SEAN M U S A,OKHAMAFE AUGUSTUS O U S A
申请号：
IN6730/CHENP/2009
公开号：
IN299803B
申请日:
2008.08.15
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
The present invention is directed to phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. The invention provides compositions of prokaryotic PAL and biologically active fragments, mutants, variants or analogs thereof, as well as methods for the production, purification, and use of such compositions for therapeutic purposes, including the treatment of cancer. US2009047265A1
