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DERIVATIVES OF 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, PREPARATION AND THERAPEUTIC USE THEREOF
专利权人:
SANOFI
发明人:
MANETTE, GERALDINE,ALTENBURGER, JEAN-MICHEL,FOSSEY, VALÉRIE,ILLIANO, STÉPHANE,MANETTE, GÉRALDINE
申请号:
MYPI 2011003011
公开号:
MY155244A
申请日:
2009.12.24
申请国别(地区):
MY
年份:
2015
代理人:
摘要:
THE INVENTION RELATES TO COMPOUNDS CORRESPONDING TO FORMULA (I), IN THE FORM OF THE BASE OR OF AN ACID-ADDITION SALT: IN WHICH N IS EQUAL TO 0, 1, 2, 3 OR 4; M IS EQUAL TO 0, 1 OR 2; O IS EQUAL TO 0 OR 1; X REPRESENTS A GROUP -CH2, -CH(R’)-, -NH(R’)- OR A HETEROATOM CHOSEN FROM O AND S, IT BEING UNDERSTOOD THAT R’ REPRESENTS A GROUP -(C1 -C5)ALKYL, -(C1-C5)ALKOXY, -CH2-ARYL, -C(O)R5 OR -COOR5; R1 REPRESENTS AN OXO GROUP, -COOR5, -W-OH OR –W-NR5R6; R2 REPRESENTS AN H ATOM OR A GROUP CHOSEN FROM THE GROUPS (I) -C1-C5)ALKYL, (II) –C1-C5ALKOXY, (III) -COOR5, (IV) -NR5R6, (V) -C(O)-NR5R6, (VI) -SO2-NR3R4, (VII) HETEROARYL OPTIONALLY SUBSTITUTED WITH A GROUP (-C1-C5)ALKYL, (VIII) -W-ARYL, (IX) W-ARYL, (IX)–W-HETEROARYL, (X) -O-W-ARYL, (XI) -O-W-HETEROARYL AND (XII) -O-W-NR5R6; IT BEING UNDERSTOOD THAT R3 AND R4, (I) WHICH MAY BE IDENTICAL OR DIFFERENT, REPRESENT, INDEPENDENTLY OF EACH OTHER, AN H ATOM, A GROUP –(C1-C5)ALKYL, -(C3-C6)CYCLOALKYL, ARYL, HETEROARYL, -CH2-HETEROARYL, -(C1-C5)ALKYL-NR5R6, -W-OH OR -WNR5R6; OR (II) FORM, TOGETHER WITH THE NITROGEN ATOM THAT BEARS THEM, A HETEROCYCLOALKYL GROUP OPTIONALLY SUBSTITUTED WITH ONE OR MORE GROUPS CHOSEN FROM THE GROUPS -(C1-C5)ALKYL AND -CH2-ARYL; W IS A GROUP -(C1-C5)ALKYLENE, OPTIONALLY SUBSTITUTED WITH ONE OR MORE HYDROXYL GROUPS; R5 AND R6, WHICH MAY BE IDENTICAL OR DIFFERENT, REPRESENT, INDEPENDENTLY OF EACH OTHER, A HYDROGEN ATOM OR A GROUP CHOSEN FROM THE GROUPS -(C1-C5)ALKYL AND THE GROUPS –(C3-C6)CYCLOALKYL, AND ALSO THE PROCESS FOR PREPARING THEM AND THE THERAPEUTIC USES THEREOF.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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