The present invention relates to compounds of formula (I) in the form of their base or acid addition salts, as well as to their preparation and therapeutic use. (I) In this formula, n is 0, 1, 2, 3 or 4； m is 0, 1 or 2； o is 0 or 1； X is -CH 2, -CH (R ') -, -NH (R') -, or O, and is a heteroatom selected from S； R 'is - (C1-C5) alkyl, - (C1-C5) alkoxy, -CH 2 - aryl, -C (O) R5 or a -COOR5； R1 is oxo, -COOR5, -W-OH or -W-NR5R6； (Ii) - (C1-C5) alkoxy, (iii) -COOR5, (iv) -NR5R6, (v) -C (O) -NR5R6 , (vi) -SO 2 -NR3R4, (vii) - (C1-C5) heteroaryl, (viii) optionally substituted with alkyl, -W- aryl, (ix) -W- heteroaryl, (x) -OW- Aryl, (xi) -OW-heteroaryl and (xii) -OR-NR5R6； R3 and R4 may be the same or different, (C 1 -C 5) alkyl, - (C 1 -C 5) alkyl, - (C 3 -C 6) cycloalkyl, aryl, heteroaryl, -CH 2 -heteroaryl, -OH or -W-NR5R6； or (ii) together with the nitrogen atom to hold them, form - aryl groups optionally substituted with one or more heteroatom selected from - (C1-C5) alkyl, and -CH 2； W represents a - (C1-C5) alkylene group optionally substituted with one or more hydroxyl groups； R5 and R6 may be the same or different and independently of one another are a hydrogen atom or a group selected from a - (C1-C5) alkyl group and a - (C3-C6) cycloalkyl group.본 발명은 염기 형태 또는 산 부가염 형태의 화학식 I의 화합물, 뿐만 아니라 상기 화합물의 제조 방법 및 치료 용도에 관한 것이다.<；화학식 I>；상기 식에서,n은 0, 1, 2, 3 또는 4이고；m은 0, 1 또는 2이고； o는 0 또는 1이고；X는 -CH2, -CH(R')-, -NH(R')-, 또는 O 및 S로부터 선택된 헤테로원자이고；R'는 -(C1-C5)알킬, -(C1-C5)알콕시, -CH2-아릴, -C(O)R5 또는 -COOR5이고； R1은 옥소, -COOR5, -W-OH 또는 -W-NR5R6이고； R2는 H 원자, 또는 (i) -(C1-C5)알킬, (ii) -(C1-C5)알콕시, (iii) -COOR5, (iv) -NR5R6, (v) -C(O)-NR5R6, (vi) -SO2-NR3R4, (vii) -(C1-C5)알킬로 임의로 치환된 헤테로아릴, (viii) -W-아릴, (ix) -W-헤테로아릴, (x) -O-W-아릴, (xi) -O-W-헤테로아릴 및 (xii) -O-W-NR5R6으로부터 선택된 기이고； R3 및 R4는 동일하거나 상이할 수 있고, (i) 서로 독립적으로 H 원자, -(C1-C5)알킬, -(C3-C6)시클로알킬, 아릴, 헤테로아릴, -CH2-헤테로아릴, -(C1-C5)알킬-NR5R6, -W-OH 또는 -W-NR5R6이거나； 또는 (ii) 그들을 보유하는 질소 원자와 함께, -(C1-C5)알킬 및 -CH2-아릴
