PROBLEM TO BE SOLVED: To focus on KLK14 which plays an important role in exfoliation of the stratum corneum, which is a process of epidermal turnover, and to use an extract of a plant which is naturally derived and unlikely to cause excessive activity fluctuation. An object of the present invention is to provide a preparation containing a plant extract that contributes to an effect of appropriately increasing the gene expression level of a precursor. In order to solve the above problems, the kallikrein precursor production promoter of the present invention is characterized by containing an extract of mussel as an active ingredient. [Selection diagram] Fig. 1【課題】本発明は、表皮のターンオーバーの過程である角層剥離において重要な役割を担うＫＬＫ１４に着目し、自然由来で過剰な活性変動を生じる可能性が少ない植物の抽出物を用いてＫＬＫ１４前駆体の遺伝子発現量を適度に高める効果に資する植物の抽出物を含有する製剤を提供することを目的とする。【解決手段】上記課題を解決するため、本発明のカリクレイン前駆体産生促進剤は、ガイヨウの抽出物を有効成分として含有することを特徴とする。【選択図】 図１
