L. David Williams;Michael S. Hershfield;Merry R. Sherman;Mark G. P. Saifer;Susan J. Kelly
发明人:
L. David Williams,Michael S. Hershfield,Susan J. Kelly,Mark G. P. Saifer,Merry R. Sherman
申请号：
US13083152
公开号：
US08618267B2
申请日:
2011.04.08
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.
