ISOLATED TETRAMERIC URICASE

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专利权人:

发明人:

申请号：

HK11109398.6

公开号：

HK1155080B

申请日:

2010.09.02

申请国别(地区):

HK

年份:

2018

代理人:

摘要：

A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to a s PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non- immunogenic and retain at least 75 % of the uricolytic activity of the unmodified enzyme.

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中国工程科技知识中心

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