MOUNTAIN VIEW PHARMACEUTICALS, INC.;DUKE UNIVERSITY
发明人:
WILLIAMS, L. DAVID,HERSHFIELD, MICHAEL S.,KELLY, SUSAN J.,SAIFER, MARK G. P.,SHERMAN, MERRY R.
申请号：
CA2728907
公开号：
CA2728907C
申请日:
1999.08.02
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.
