MICHAEL S. HERSHFIELD,SUSAN J. KELLY,MERRY R. SHERMAN,MARK G. P. SAIFER,DAVID L. WILLIAMS
申请号：
PT09175303
公开号：
PT2158923E
申请日:
1999.08.02
申请国别(地区):
PT
年份:
2013
代理人:
摘要：
A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.
