NY STATE PSYCHIATRIC INSTITUTE;THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人:
DONALD LANDRY,KAREN DUFF,KIRSTEN ALISON RINDERSPACHER,SHI-XIAN DENG,WAI YU
申请号：
BR112018006873
公开号：
BR112018006873A2
申请日:
2016.10.05
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The present application discloses compounds which are autophageal flow activators and pharmaceutical compositions comprising said activators. It further discloses the use of said compounds and pharmaceutical compositions in the treatment of neurodegenerative diseases, particularly proteinopathies and tauopathies, such as Alzheimer's disease. It further discloses methods for increasing autophageal flow.o presente pedido divulga compostos que são ativadores do fluxo autofágico e composições farmacêuticas que compreendem os referidos ativadores. este divulga ainda o uso dos referidos compostos e composições farmacêuticas no tratamento de doenças neurodegenerativas, particularmente proteinopatias e tauopatias, tais como o mal de alzheimer. este divulga ainda métodos para aumentar o fluxo autofágico.
