Ramón Berenguer Maimó;Joan Gabriel Solsona Rocabert;Marti Bartra Sanmartí
发明人:
Marti Bartra Sanmartí,Ramón Berenguer Maimó,Joan Gabriel Solsona Rocabert
申请号：
US13577827
公开号：
US08680284B2
申请日:
2011.02.11
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A preparation process of esomeprazole sodium substantially free of sulfone impurity including the steps of: a) combining either esomeprazole with a (C3-C8)-ketone or a mixture thereof, a sodium alkoxide, and a (C1-C5)-alcohol, or esomeprazole sodium with a (C3-C8)-ketone or a mixture thereof and a (C1-C5)-alcohol； and b) recovering the esomeprazole sodium formed from the reaction media by filtration.
