Bartra Sanmarti, Marti,Berenguer Maimo, Ramon,Solsona Rocabert, Joan Gabriel
申请号：
AU2011214300
公开号：
AU2011214300A1
申请日:
2011.02.11
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Preparation process of the sodium salt of a 2-(2-pyridylmethylsulfinyl)- benzimidazole derivative compound It comprises a preparation process of esomeprazole sodium substantially free of sulfone impurity comprising the steps of: a) combining either esomeprazole with a (C-C)-ketone or a mixture thereof, a sodium alkoxide, and a (C-C)-alcohol, or esomeprazole sodium with a (C-C)-ketone or a mixture thereof and a (C-C)-alcohol； and b) recovering the esomeprazole sodium formed from the reaction media by filtration.
