The present invention is a method for producing a vesicle composition having an aqueous phase as a continuous phase, the method including a step of dissolving an oil phase containing component (A) a branched fatty acid having a predetermined structure； component (B) a tertiary amine having a predetermined structure； and component (C) an organic acid having 1 to 10 carbon atoms at a temperature that is equal to or higher than a melting point of the oil phase, and a step of carrying out mixing while adding the aqueous phase to the oil phase which is dissolved.本發明提供一種囊胞組合物之製造方法，其包含：使含有成分(A)具有特定結構之支鏈脂肪酸、成分(B)具有特定結構之三級胺、及成分(C)碳數1~10之有機酸之油相，於該油相之熔點以上之溫度溶解之步驟；及一面向經溶解之油相中添加水相一面混合之步驟；且該囊胞組合物之連續相為水相。
