Omar Khaled Ahmad,Stephen Paul Brown,Kenneth John Dirico,Russell Dushin,Gary Frederick Filzen,Sujiet Puthenveetil,Pavel Strop,Chakrapani Subramanyam,Lawrence N. Tumey
申请号:
US16477290
公开号:
US20190345186A1
申请日:
2018.01.10
申请国别(地区):
US
年份:
2019
代理人:
摘要:
The present invention is directed to novel calicheamicin derivatives useful as payloads in antibody-drug-conjugates (ADC's), and to payload-linker compounds and ADC compounds comprising the same; to pharmaceutical compositions comprising the same and to methods for using the same to treat pathological conditions such as cancer.