The present invention relates, in particular, to a pharmaceutical composition comprising the non-saponifiable moieties derived from a least one lipid of natural, vegetable and/or animal origin, for use in the treatment of those infective pathologies, such as AIDS and/or diabetic foot and/or diabetes and/or general systemic infections, even non-responding to other treatments of any origin (such as fungal, bacterial, viral) and/or septicaemia and/or exanthematous pathologies, chickenpox, zoster, measles, hand-foot-mouth diseases, contagious mollusc and/or hepatitis and/or pneumonias and/or renal infections and/or osteomyelitis and/or fistulizations, and/or necrotizing fascitis and/or condylomas and/or cystitis, which are caused by the permanent (or chronic) alteration (or imbalance) of the normal physiological equilibrium of the steroidal balance in an individual suffering from said pathology and/or of those peripheral neuropathologies such as diabetic neuropathies and/or thalassaemia major and/or thrombocytopenia and/or algodystrophy and/or carpal tunnel, which are caused by permanent (or chronic) alteration (or imbalance) of the normal physiological equilibrium of the steroidal balance in an individual suffering from said pathology. Said pharmaceutical composition is particularly adapted for transdermal and/or transmucosal topical administration.La présente invention concerne, en particulier, une composition pharmaceutique comprenant les fractions non saponifiables dérivées dau moins un lipide dorigine naturelle, végétale et/ou animale, destinée à être utilisée dans le traitement de ces pathologies infectieuses, telles que le SIDA et/ou le pied diabétique et/ou le diabète et/ou les infections systémiques générales, y compris celles ne répondant pas à dautres traitements de nimporte quelle origine (telle que fongique, bactérienne, virale) et/ou la septicémie et/ou des pathologies exanthémateuses, la varicelle, le zona, la rougeole, des maladies infectieuses des pieds
