The present invention relates, in particular, to a pharmaceutical composition comprising the non-saponifiable moieties derived from a least one lipid of natural, vegetable and/or animal origin, for use in the treatment of those infective pathologies, such as AIDS and/or diabetic foot and/or diabetes and/or general systemic infections, even non-responding to other treatments of any origin (such as fungal, bacterial, viral) and/or septicaemia and/or exanthematous pathologies, chickenpox, zoster, measles, hand-foot-mouth diseases, contagious mollusc and/or hepatitis and/or pneumonias and/or renal infections and/or osteomyelitis and/or fistulizations, and/or necrotizing fascitis and/or condylomas and/or cystitis, which are caused by the permanent (or chronic) alteration (or imbalance) of the normal physiological equilibrium of the steroidal balance in an individual suffering from said pathology and/or of those peripheral neuropathologies such as diabetic neuropathies and/or thalassaemia major and/or thrombocytopenia and/or algodystrophy and/or carpal tunnel, which are caused by permanent (or chronic) alteration (or imbalance) of the normal physiological equilibrium of the steroidal balance in an individual suffering from said pathology. Said pharmaceutical composition is particularly adapted for transdermal and/or transmucosal topical administration.