The present invention relates in particular to a pharmaceutical composition comprising the non-saponifiable moieties obtained from lipids of natuiral vegetable origin for use in the treatment of those rheumatic diseases, such as rheumatoid arthritis and/or lupus and/or rheumatic polymyalgia and/or ankylosing spondylitis and/or psoriatic arthritis and/or SLE (Lupus Erythematosus Systemic) and/or polymyositis and/or dermatomyositis and/or osteoarthritis and/or tenosynovitis and/or gout, which are caused by the permanent (or chronic) alteration (or imbalance) of the normal physiological equilibrium of the steroidal balance and also of pathologies, such as Alzheimer's disease, scleroderma, Crohn's disease and/or Sjogren's syndrome, which are caused by the permanent (or chronic) alteration (or imbalance) of the normal physiological equilibrium of the steroidal balance in a patient suffering from this chronic pathology. Said pharmaceutical composition is particularly adapted for transdermal and/or transmucosal topical administration.
