The present invention concerns a new further use of non-saponifiable fractions obtained from lipids of natural origin, both vegetable and animal, for the therapeutic treatment of permanent chronic pathological change of the steroidal balance outside the natural physiological equilibrium of its components in a patient suffering from this chronic pathological condition. In particular, the invention refers to the aforementioned fractions of non-saponifiable compounds for use in the treatment of permanent chronic pathological change of the steroidal balance (and also in the treatment of those chronic, relapsing or progressive pathologies, which are caused by the same), inducing the rebalancing of its components within the natural physiological levels. In particular, the invention also refers to a pharmaceutical composition of said non- saponifiable compounds for use in the treatment of permanent chronic pathological change of the steroidal balance (and also in the treatment of those chronic, relapsing or progressive pathologies, which are caused by the same), inducing the rebalancing of its components within the natural physiological levels. Said pharmaceutical composition is particularly suitable for transdermal and/or transmucosal adminstration.
