GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
发明人:
HILARY SCHENCK EIDAM,ZHILIU ZHANG,HAIYU YU,MICHAEL P. DEMARTINO,ZHEN GONG,HUIPING GUAN,KAUSHIK RAHA,CHENGDE WU,HAIYING YANG
申请号：
ARP140101009
公开号：
AR095308A1
申请日:
2014.03.14
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
2-pyridane, an inhibitor of quinolase, is reconstituted during blood transfusion,represented by the formula (1) wherein: R¹ is hydrogen, halogen, C₁₋₆ alkyl,C₁₋₆ haloalkyl,C₃₋₆ cycloalkyl,Hydroxy, alcoxi c83216c833126；C₁₋₆ haloalkoxy,C₃₋₆ cycloalkoxy,amino (alquil C) amino-o (alquil C) (alquil C) amino-each R² is independently selected from the group consisting of halogen, C₁₋₆ alkyl,C₁₋₆ haloalkyl,C₃₋₆ cycloalkyl,ciano hidroxilo alcoxi CC₁₋₆ haloalkoxy,C₃₋₆ cycloalkoxy,amino (alquil C) amino-y (alquil C) (alquil C) amino-R³ is 5 or 6 membered phenyl or heteroaryl, each of which is optionally substituted with one to three substituents independently selected from halogen, C₁₋₆ alkyl,C₁₋₆ haloalkyl,C₃₋₆ cycloalkyl,Ciano, heterosexual, 5 or 6 members,And conr8309； r8310；wherein said C₁₋₆ alkyl is optionally substituted with cyano, hydroxyl, C₁₋₄ alkoxy,C₁₋₄ haloalkoxy,or -NR⁵R⁶；and wherein said 5 or 6 membered heteroaryl substituent is optionally substituted with halogen, C₁₋₄ alkyl,O halogenated tar c831832421；R83088 is hydrogen, c832131 matrix 832626；C₁₋₆ haloalkyl,C₃₋₆ cycloalkyl,or 4-6 membered heterocycloalkyl； wherein said C₁₋₆ alkyl is optionally substituted with cyano, hydroxyl, C₁₋₄ alkoxy,C₁₋₄ haloalkoxy,or -NR⁵R⁶；and wherein said C₃₋₆ cycloalkyl is optionally substituted with one or two substituents independently selected from C₁₋₄ alkyl,C₁₋₄ haloalkyl,Hydroxyl group；C₁₋₄ alkoxy,a. Halogenated alcoxi c8321c833183242；and wherein said 4- to 6-membered heterocycloalkyl is optionally substituted with one or two substituents independently selected from C₁₋₄ alkyl and C₁₋₄ haloalkyl；R83099a and r8310a should be independent of the hydrocarbon group composed of hydrogen and c832131；a. Halogenated tar c831832421；or R⁵ and R⁶ taken together with the nitrogen to which they are attached represent a saturated ring of 5 or 6 members, optionally containing an additional heteroatom selected from oxygen, nitrogen, and sulfur, wherein said ring is optionally substituted with
