This invention provides a compound represented by a general formula (I) wherein Ro is -C(=O)NRa-, -S(=O)2NRa-, -C(=O)O- or single bond etc., R1 is hydrogen atom, alkyl, alkene, optionally hetero atom-containing 3 to 6 member saturated- or 4 to 6 member unsaturated- aliphatic ring or optionally hetero atom-containing 5 to 6 member aromatic ring etc., R2 is hydrogen atom or alkyl etc., R3 and R4 are each independently hydrogen atom or alkyl etc., L is 5 to 6 aromatic ring or -S(=O)q-, Ar1 and Ar2 are each independently optionally hetero atom-containing 5 to 6 member aromatic ring substituted at one or more position(s), or a pharmaceutically acceptable salt there of, and an agent for prophylaxis and/or treatment of various kinds of inflammatory disease involving elastase comprising the same as an active ingredient.本發明係提供一種下述通式(I)所示之化合物或者其生理上容許之鹽(式中，R0表示-C(=O)NRa-、-S(=O)2NRa-、-C(=O)O-、單鍵等，R1表示氫原子、烷基、烯基、可含有雜原子之3至6員飽和或4至6員不飽和的脂肪族環、或可含有雜原子之5至6員芳族環等，R2表示氫原子、烷基等，R3及R4分別獨立表示氫原子、烷基等，L表示5至6員之芳族環或-S(=O)q-，Ar1及Ar2分別獨立表示於1處以上的位置經取代之可含有雜原子之5至6員芳族環基)，以及含有該化合物等作為活性成分之用於彈性蛋白酶所涉及之各種發炎性疾病的預防及/或治療劑。
