您的位置: 首页 > 农业专利 > 详情页

GPR120 RECEPTOR AGONISTS AND USES THEREOF
专利权人:
发明人:
申请号:
HK13104893.5
公开号:
HK1177742A
申请日:
2013.04.23
申请国别(地区):
HK
年份:
2013
代理人:
摘要:
GPR120 agonists are provided. These compounds are useful for the treatment of Metabolic Diseases, including Type II Diabetes and diseases associated with poor control of blood glucose.Claim 1: a compound characterized in that responds to the formula (1) or a pharmaceutically acceptable Salt thereof, where the Group J is absent or is selected from the group consisting of formulas (2) The Ring q is selected from the group consisting of aryl, lo Roarilo Group, Formula 3, where q is replaced with optional (r6) K A1, A2.A3 and A4 are selected independently from the group which consists of N and C, with the condition that only 0, 1 or 2 A1, A2, A3 and A4 is n T1, T2, T3 and T4 are selected independently from the group consisting of N, o, and CR1 cr1r2, with the condition that only 0, 1 or 2 t 1, T2, T3 and T4 is selected from W and W1, W2, orW3 and W4 are selected independently from the group consisting of N, NRA, CR1, cr1r2, o, S, S (or S) and (OR) 2, with the condition that the J is not 1,3-dioxolane Ring E1, E2 and E3 are selected independently from the group that is one of C and N X and y is a Union, - CH2 -, - CHD - or - CD, and the other of X and y is selected from the group consisting of - CH2 - - - - - CHD, CD2,- C (o) - C (o) - NRA, the NRA -, - O -, - S, - S - S - (o) and (OR) 2 - L - (cr4r5) Q - where an optional - (cr4r5) - replaced with - N -, or - -, - S -, - CR4 = CR5 -, or - phenyl - g is selected from the group consisting of Oz and - C (o) - C (o) z NZ2 each is selected independently from the group consisting of H,Alkyl and substituted alkyl each R1 and R2 are independently selected from the group consisting of H, alkyl, Halo, deuterium substituted cycloalkyl substituted alkyl, cycloalkyl, alquenilo, alquenilo, replaced, alquinilo, alquinilo substituted OXO, alkoxy, substituted alkoxy, CN Nrarb, -, - C (o) C (o) - ra, ora, - C (o) nrarb, NRAC (or RB), -, - S - S (o) and (OR) ra 2RA,And optionally R1 and R2 can be ciclizar to form a heterociclilo C3 C3 - 7
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
相关发明人
相关专利

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充