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Agent for the treatment or prevention of diseases associated with the activity of neurotrophic factors
专利权人:
SUMITOMO CHEMICAL COMPANY; LIMITED
发明人:
ISHIKAWA, JUNICHI,SAITO, KOICHI,OHE, NORIHISA,KOBAYASHI, KENTARO
申请号:
ES10780309
公开号:
ES2484169T3
申请日:
2010.05.28
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A compound represented by the formula: wherein, R1 represents: (1) a C3-6 alkyl group, (2) a C1-6 alkyl group substituted with one or more substituent groups selected from those consisting of: (a ) a halogen atom, (b) a Ra-O- group, (c) a Ra-O-CO- group, (d) a Ra-O-CO-NRa- group, (e) a Ra-O group -CO-C2H4-CO-NH-, (f) a Ra-S- group, (g) a Ra-SO2- group, (h) a Ra-CO-O- group, (i) a Ra-CO group -NRa-, (j) a Ra-NRa- group, (k) a Ra-NRa-CS-NRa- group, (l) an annular group of 5 to 6 members, (m) a carboxy group, (n) a hydroxy group, (o) an amino group, (p) a heterocyclic carbonyl group, (q) a HO-CO-C2H4-CO-NH- group (in which, each Ra is the same or different, and represents a group C1-6 alkyl optionally substituted with halogen), or (3) a non-aromatic C3-10 cyclic hydrocarbon group or a 5- to 6-membered non-aromatic heterocyclic group that are optionally substituted with one or more groups of substituents selected two among those consisting of: (a) an oxo group, and (b) a C1-4 alkoxycarbonyl group, (4) an aromatic cyclic hydrocarbon group substituted with one or more substituents selected from the group consisting of a halogen atom and a C1-4 alkoxy group, X represents NH, O, or S, Y represents CH or N, Z represents N or a C-R2 group, R2 represents: (1) a C1-6 alkyl group, a C2 alkenyl group -6 or a C2-6 alkynyl group that are respectively optionally substituted with one or more substituent groups selected from those consisting of: (a) a halogen atom, (b) an Rb-O- group, (c) a group Rb-O-CO-, (d) a group Rb-O-CO-NRb-, (e) a group Rb-S-, (f) a group Rb-SO2-, (g) a group Rb-CO -O-, (h) a group Rb-CO-NRb-, (i) a group Rb-NRb-, (j) a group Rb-CO-NRb-Rb-S (O) n-,Un compuesto representado por la fórmula: en la que, R1 representa: (1) un grupo alquilo C3-6, (2) un grupo alquilo C1-6 sustituido con uno o más grupos de sustituyentes seleccionados entre aquellos que consisten en: (a) un átomo de halógeno, (b) un grupo Ra-O-, (c) un grupo Ra-O-CO-, (d) un grupo Ra-O-CO-NRa-, (e) un
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