MA, YUPO,PINZ, KEVIN,JIANG, XUN,WADA, MASAYUKI,CHEN, KEVIN
申请号：
CA3078735
公开号：
CA3078735A1
申请日:
2018.10.12
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
In one embodiment, the present disclosure provides an engineered cell having a first chimeric antigen receptor polypeptide including a first antigen recognition domain, a first signal peptide, a first hinge region, a first transmembrane domain, a first co- stimulatory domain, and a first signaling domain； and a second chimeric antigen receptor polypeptide including a second antigen recognition domain, a second signal peptide, a second hinge region, a second transmembrane domain, a second co- stimulatory domain, and a second signaling domain； wherein the first antigen recognition domain is different than the second antigen recognition domain.
