Compound Chimeric Antigen Receptor (CCAR) Targeting Multiple Antigents, Compositions and Methods of Use Thereof

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专利权人:

ICELL GENE THERAPEUTICS; LLC

发明人:

Yupo Ma,Kevin PINZ,Xun Jiang,Masayuki Wada,Kevin Chen

申请号：

US16753951

公开号：

US20200308541A1

申请日:

2018.10.12

申请国别(地区):

US

年份:

2020

代理人:

摘要：

In one embodiment, the present disclosure provides an engineered cell having a first chimeric antigen receptor polypeptide including a first antigen recognition domain, a first signal peptide, a first hinge region, a first transmembrane domain, a first costimulatory domain, and a first signaling domain； and a second chimeric antigen receptor polypeptide including a second antigen recognition domain, a second signal peptide, a second hinge region, a second transmembrane domain, a second co-stimulatory domain, and a second signaling domain； wherein the first antigen recognition domain is different than the second antigen recognition domain.

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中国工程科技知识中心

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http://www.ckcest.cn/home/