CONSTRUCT COMPRISING RECOGNITION DOMAIN OF ANTIBODY AGAINST VON WILLEBRAND FACTOR-SPECIFIC CLEAVING ENZYME

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专利权人:

发明人:

申请号：

EP04721377.2

公开号：

EP1609804B1

申请日:

2004.03.17

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

The present invention provides an epitope recognized by an antibody (hereinafter, also referred to as an anti-ADAMTS-13 antibody) against a cleaving protease (hereinafter, also referred to as ADAMTS-13) specific to von Willebrand factor (hereinafter, also referred to as vWF), and a polypeptide comprising the epitope region. The present invention also provides a polypeptide located in a region from position 449 to position 687 in an amino acid sequence composing the ADAMTS-13, which is recognized by the anti-ADAMTS-13 antibody, or a peptide fragment derived from the polypeptide.

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