Alfred Hahn,Ralf Loebbert,Nicole Teusch,Achim Möller,Ulrich Ebert,Martin Schmidt
申请号：
US14993308
公开号：
US20170008959A1
申请日:
2016.01.12
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to the identification, functionality and use of domains from the N terminus of the receptor for Advanced Glycation End Products (AGER). These domains, called receptor mulitimerization epitope (RME), are highly conserved in all AGER protein sequences. They represent the mediators for AGER self-association and heteromerization with other proteins. The invention likewise relates to the identification, functionality and use of peptides derived from the C domain of AGER (AGER-CDP). The AGER RMEs and AGER-CDPs of the invention are suitable as target for identifying AGER ligands which modulate the natural ligand interaction as immunogen for active or passive immunization of individuals, as diagnostic means for identifying immunogenic reactions, and as peptide ligands for modulating protein-protein interactions involving AGER.
