PEPTIDES NEUROPROTECTEURS QUI INHIBENT UNE INTERACTION ENTRE UNE PALMITOYL ACYLTRANSFÉRASE À DOIGT DE ZINC DHHC DE TYPE CONTENANT 17 (ZD17) ET UNE C-JUN N-TERMINAL KINASE (JNK)

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专利权人:

THE UNIVERSITY OF BRITISH COLUMBIA

发明人:

CYNADER, MAX S.,YANG, GUANG

申请号：

EP12811167

公开号：

EP2732032A4

申请日:

2012.07.12

申请国别(地区):

EP

年份:

2015

代理人:

摘要：

Isolated polypeptides are disclosed herein, the isolated polypeptides comprising at least 90% identity to any one of: SEQ ID NO:1； SEQ ID NO:2； or SEQ ID NO:3, wherein the isolated polypeptide inhibits an interaction between palmitoyl acyl transferase zinc-finger DHHC type containing 17 (z D17) and c-jun N-terminal kinase (JNK). The polypeptides may be conjugated to a delivery and targeting moiety, such as the cell-membrane transduction domain of the HIV-1 Tat protein. There are also provided methods for treating a disease associated with cytotoxicity or excitotoxicity.

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