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BACTERIAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF DEGENERATIVE DISEASE
专利权人:
МАЙКРОФАРМА ЛИМИТЕД (CA)
发明人:
ПРАКАШ Сатия (CA),ДЖОУНС Митчелл Лоуренс (CA),МАРТОНИ Кристофер (CA)
申请号:
RU2011148944/10
公开号:
RU2011148944A
申请日:
2010.04.30
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. An oral composition containing bacteria with high bsh activity, their isolate or supernatant, where bacteria with high activity degrade>; 50 μmol GDCA / gram / hour and>; 2 μmol TDCA / gram / hour when measured after 1 hour and 5 hours, respectively, or>; 65 μmol GDCA / g / h; and>; 7 μmol TDCA / g / h when measured after 30 minutes. 2. The oral composition of claim 1, wherein bacteria with high bsh activity degrade>; 300 μmol GDCA / g / h and>; 40 μmol TDCA / g / hr when measured after 30 minutes. The oral composition of claim 1, wherein bacteria with high bsh activity degrade>; 2000 μmol GDCA / g / h and>; 500 μmol TDCA / g / h when measured after 30 minutes. The oral composition of claim 1, wherein the bacteria with high bsh activity degrade>; 15,000 μmol GDCA / g / h and>; 2000 μmol TDCA / g / hr measured after 30 minutes. An oral composition according to claim 1, further comprising a carrier. The oral composition of claim 1, wherein the bacteria are alive. The oral composition of claim 1, wherein the bacteria are free. The oral composition of claim 1, wherein the bacteria are Lactobacillus, Bifidobacteria, Pediococcus, Streptococcus, Enterococcus or Leuconostoc. 9. The oral composition of claim 8, wherein is Lactobacillus reuteri. 10. The oral composition of claim 9, wherein Lactobacillus reuteri is Lactobacillus reuteri (NCIMB 701359), Lactobacillus reuteri (NCIMB 701089), Lactobacillus reuteri (ATCC 55148), Lactobacillus reuteri (ATCC 23272), Lactobus reuteri (ATCC 23272), Lactobus reuteri (ATCC 23272) LMG 18238), Lactobacillus reuteri (CCUG 32271), Lactobacillus reuteri (CCUG 32305), Lactobacillus reuteri (CCUG 37470), Lactobacillus reuteri (CCUG 44001) or Lactobacillus reuteri (CCUG 44144). 11. The oral composition of claim 1, wherein the concentration of bacteria is 10-10 CFU / gram. The oral composition according to claim 1, wherein bacteria with high bsh activity are grown under fermentation conditions, including a carbon source, a
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