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PROCESS FOR PREPARING HYPROMELLOSE HARD CAPSULE USING THERMOGELATION
专利权人:
LTD.;SUHEUNG CO.
发明人:
Joo-Hwan YANG
申请号:
US15941924
公开号:
US20190224128A1
申请日:
2018.03.30
申请国别(地区):
US
年份:
2019
代理人:
摘要:
The present invention relates to a process for preparing hypromellose hard capsule using thermogelation with improved storage stability, film strength, film distribution, filling up performance and/or bioavailability of ingredient. More specifically, this invention relates to a process for preparing hypromellose hard capsule using thermogelation with improved storage stability, film strength, film distribution, filling up performance and/or bioavailability of ingredient, comprising the steps of: i) sequentially adding and solubilizing 0.1-0.5 wt part of plasticizer, 0.1-0.5 wt part of wetting agent and a small amount of a viscosity stabilizer to the 100 wt part of hypromellose aqueous dispersion containing 19-22 wt part of hypromellose; ii) adjusting the viscosity of the mixture into 800-1,300 cP; iii) dipping the mold pin into the hypromellose aqueous solution maintained at 19-21° C. after preheating the mold pin to be 100-120° C.; and iv) forming the hypromellose hard capsule.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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