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PROCÉDÉ DE PRÉPARATION D'UNE CAPSULE DURE D'HYPROMELLOSE PAR THERMOGÉLATION
专利权人:
Ltd.;Suheung Co.
发明人:
申请号:
EP18163408.0
公开号:
EP3513785A1
申请日:
2018.03.22
申请国别(地区):
EP
年份:
2019
代理人:
摘要:
The present invention relates to a process for preparing hypromellose hard capsule using thermogelation with improved storage stability, film strength, film distribution, filling up performance and/or bioavailability of ingredient. More specifically, this invention relates to a process for preparing hypromellose hard capsule using thermogelation with improved storage stability, film strength, film distribution, filling up performance and/or bioavailability of ingredient, comprising the steps of: i) sequentially adding and solubilizing 0.1-0.5 wt part of plasticizer, 0.1-0.5 wt part of wetting agent and a small amount of a viscosity stabilizer to the 100 wt part of hypromellose aqueous dispersion containing 19-22 wt part of hypromellose; ii) adjusting the viscosity of the mixture into 800-1,300 cP; iii) dipping the mold pin into the hypromellose aqueous solution maintained at 19-21 °C after preheating the mold pin to be 100-120 °C; and iv) forming the hypromellose hard capsule.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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