PROBLEM TO BE SOLVED: To provide a transdermal absorption formulation including a support body, an adhesive layer and a liner, capable of suppressing transdermal permeation of an adrenal cortical steroid medical agent included in the adhesive layer, capable of continuously achieving transdermal absorption of the agent in an enough amount to develop the effect of the agent for a long period of time, showing no decrease in the adhesive characteristic of the adhesive, and giving little cutaneous stimulation.SOLUTION: The transdermal absorption formulation includes a support body, a polyisobutylene adhesive layer and a liner, in which the polyisobutylene adhesive layer contains an adrenal cortical steroid medical agent and preferably 0.1 to 5.0 mass% of a vinyl acetate resin. The vinyl acetate resin is used as a transdermal permeation inhibitor for the transdermal absorption formulation.COPYRIGHT: (C)2013,JPO&INPIT【課題】支持体、粘着剤層、及びライナーを備える経皮吸収製剤であって、粘着剤層中に含有される副腎皮質ステロイド薬剤の皮膚透過を抑制して、長期間にわたり、薬剤の効果の発現に充分な量の薬剤を持続的に経皮吸収させることができるとともに、粘着剤の粘着特性が損なわれず、皮膚刺激も少ない経皮吸収製剤を提供すること。【解決手段】支持体、ポリイソブチレン粘着剤層、及びライナーを備える経皮吸収製剤であって、ポリイソブチレン粘着剤層が、副腎皮質ステロイド薬剤、及び、好ましくは0.1~5.0質量%の酢酸ビニル樹脂を含有することを特徴とする前記経皮吸収製剤、並びに、経皮吸収製剤の皮膚透過抑制剤としての酢酸ビニル樹脂の使用。【選択図】なし
