Photoactivatable receptors and their uses

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专利权人:

University of Rochester

发明人:

Kim, Minsoo

申请号：

AU2012275392

公开号：

AU2012275392A1

申请日:

2012.06.28

申请国别(地区):

AU

年份:

2014

代理人:

摘要：

Provided herein is a chimeric photoactivatable polypeptide comprising an opsin membrane receptor, wherein an intracellular domain of the opsin membrane receptor is replaced with a corresponding intracellular domain of a chemokine receptor, a sphingosine-1-phosphate receptor or an ATP receptor and uses thereof. Further provided are methods of treating cancer, injury of the nervous system, autoimmune disease, and graft rejection comprising administering to the subject a cell that expresses the chimeric photoactivatable polypeptide and exposing the cell to a visible light source.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/