Reversing the effects of the tumor microenvironment using chimeric cytokine receptors

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专利权人:

BAYLOR COLLEGE OF MEDICINE

发明人:

LEEN ANN MARIE,VERA JUAN F.

申请号：

NZ71081012

公开号：

NZ710810A

申请日:

2012.04.05

申请国别(地区):

NZ

年份:

2016

代理人:

摘要：

Discloses an isolated immune system cell comprising a chimeric cytokine receptor comprising a cytokine-binding exodomain and a signal transducing endodomain, wherein (a) the exodomain comprises an IL-10 receptor exodomain, a TGFbeta receptor exodomain, an IL-6 receptor exodomain, an IL-8 receptor exodomain, or a combination thereof, and (b) the endodomain comprises an IL-2 receptor endodomain, an IL-7 receptor endodomain, an IL-15 receptor endodomain, or a combination thereof. Also discloses related methods of producing such cells and use in treating cancer.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/