The invention provides a compound that inhibits or modulates p70s6 kinase activity, the compounds being of formula (1): (1) or a salt, tautomer or n-oxide thereof； wherein: one of y and z is r3 and the other is ar2； q1 is an optionally substituted C1-8 alkylene group； and wherein a carbon atom of the C1-8 alkylene group may be optionally substituted by a cyclopropane-1,1-diyl or cyclobutane-1,1-diyl group, provided that the total number of carbon atoms in an alkylene group which contains such substitution does not exceed 8； q2 is a bond or optionally substituted C1-8 alkylene group； r1 is selected from hydrogen, nrxry and a cy1 group； R x and R y are each selected from hydrogen, C 1-4 hydrocarbyl or hydroxy hydrocarbyl 1-4； or nrxry forms an optionally substituted 4- to 7-membered heterocyclic ring； cy1 is a monocyclic 3 to 7 membered non-aromatic monocyclic or carbocyclic carbocyclic optionally substituted； R 2 and R 4 are each selected from hydrogen, fluorine, chlorine, optionally substituted C 1-2 alkyl and optionally substituted C 1-2 alkoxy； R3 is selected from hydrogen, fluorine, chlorine, optionally substituted C1-2 alkyl and optionally substituted C1-2 alkoxy； ar1 is an optionally substituted monocyclic 5- or 6-membered heteroaryl or aryl ring； and ar 2 is an optionally substituted 8 to 11 membered bicyclic heteroaryl group. The compounds are useful in medicine, for example in the treatment of a selected disease or condition from cancers, neurodevelopmental diseases and neurodegenerative diseases.a invenção fornece composto que inibe ou modula a atividade da quinase p70s6, os compostos sendo da fórmula (1): (1) ou um sal, tautômero ou n-óxido dos mesmos； em que: um dentre y e z é r3 e o outro é ar2； q1 é um grupo alquileno c1-8 opcionalmente substituído； e em que um átomo de carbono do grupo alquileno c1-8 pode ser substituído opcionalmente por um grupo ciclopropano-1,1-diila ou ciclobutano-1,1-diila, contanto que o número total de átomos de carbono em um gr
