ANTONIO RICCI,BARBARA BIEMANS,DANIEL RUEHER,ERIC VIEIRA,GEORG JAESCHKE,WOLFGANG GUBA
申请号：
BR112016005994
公开号：
BR112016005994A2
申请日:
2014.09.22
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
compounds of formula i, wherein y is n or c-R 1 '； g is a 5- or 6-membered aromatic or heteroaromatic ring containing 0, 1, 2 or 3 heteroatoms selected from the group consisting of phenyl, pyridinyl with different positions of n, imidazolyl, pyrazinyl, pyrimidinyl, thiophenyl, thiazolyl, pyrazolyl or thiadiazolyl, optionally substituted by 1, 2 or 3 substituents, selected from the group consisting of halogen, lower alkyl, lower alkoxy, lower alkoxy substituted by halogen or nrr '； independently of each other are hydrogen or lower alkyl or may form together with the n atom to which they are attached a saturated five- or six-membered heterocyclic group which may contain oxygen, an nh or n-alkyl group additional bottom； R1 is hydrogen, halogen or lower alkyl substituted by halogen； R1 'is hydrogen, halogen or lower alkyl substituted by halogen； R2 is hydrogen, lower alkyl, lower alkoxyalkyl, cycloalkyl or heterocycloalkyl； or R2 may together with the nearest carbon atom in group g form a group (ia) to be -ch2-, -ch2ch2, or -c (ch3) 2； R3 is phenyl or pyridinyl, where the n atom in the pyridinyl group may be in different positions； or to a pharmaceutically acceptable salt or acid addition salt, a racemic mixture or its enantiomers and / or optical isomers and / or corresponding stereoisomers thereof.compostos de fórmula i, em que y é n ou c-r1'； g é um anel aromático ou heteroaromático com 5 ou 6 membros que contém 0, 1, 2 ou 3 heteroátomos, selecionados do grupo que consiste em fenila, piridinila com diferentes posições de n, imidazolila, pirazinila, pirimidinila, tiofenila, tiazolila, pirazolila ou tiadiazolila, opcionalmente substituídas por 1, 2 ou 3 substituintes, selecionados do grupo que consiste em halogênio, alquila inferior, alcoxila inferior, alcoxila inferior substituída por halogênio ou nrr'； r e r' são, independentemente um do outro, hidrogênio ou alquila inferior ou podem formar junto com o átomo de n ao qual eles estão acoplados, um grupo heterocíclico s
