ANTONIO RICCI,BARBARA BIEMANS,DANIEL RUEHER,ERIC VIEIRA,GEORG JAESCHKE,WOLFGANG GUBA
申请号:
BR112016005994
公开号:
BR112016005994A2
申请日:
2014.09.22
申请国别(地区):
BR
年份:
2017
代理人:
摘要:
compounds of formula i, wherein y is n or c-R 1 '; g is a 5- or 6-membered aromatic or heteroaromatic ring containing 0, 1, 2 or 3 heteroatoms selected from the group consisting of phenyl, pyridinyl with different positions of n, imidazolyl, pyrazinyl, pyrimidinyl, thiophenyl, thiazolyl, pyrazolyl or thiadiazolyl, optionally substituted by 1, 2 or 3 substituents, selected from the group consisting of halogen, lower alkyl, lower alkoxy, lower alkoxy substituted by halogen or nrr '; independently of each other are hydrogen or lower alkyl or may form together with the n atom to which they are attached a saturated five- or six-membered heterocyclic group which may contain oxygen, an nh or n-alkyl group additional bottom; R1 is hydrogen, halogen or lower alkyl substituted by halogen; R1 'is hydrogen, halogen or lower alkyl substituted by halogen; R2 is hydrogen, lower alkyl, lower alkoxyalkyl, cycloalkyl or heterocycloalkyl; or R2 may together with the nearest carbon atom in group g form a group (ia) to be -ch2-, -ch2ch2, or -c (ch3) 2; R3 is phenyl or pyridinyl, where the n atom in the pyridinyl group may be in different positions; or to a pharmaceutically acceptable salt or acid addition salt, a racemic mixture or its enantiomers and / or optical isomers and / or corresponding stereoisomers thereof.compostos de fórmula i, em que y é n ou c-r1'; g é um anel aromático ou heteroaromático com 5 ou 6 membros que contém 0, 1, 2 ou 3 heteroátomos, selecionados do grupo que consiste em fenila, piridinila com diferentes posições de n, imidazolila, pirazinila, pirimidinila, tiofenila, tiazolila, pirazolila ou tiadiazolila, opcionalmente substituídas por 1, 2 ou 3 substituintes, selecionados do grupo que consiste em halogênio, alquila inferior, alcoxila inferior, alcoxila inferior substituída por halogênio ou nrr'; r e r' são, independentemente um do outro, hidrogênio ou alquila inferior ou podem formar junto com o átomo de n ao qual eles estão acoplados, um grupo heterocíclico s