KAMOGAWA, YUMIKO,CHO, MINKWON,ARAI, NAOKO,ISHIDA, KOJI
申请号：
ES06842945
公开号：
ES2416716T3
申请日:
2006.12.20
申请国别(地区):
ES
年份:
2013
代理人:
摘要：
A monoclonal antibody that binds to an extracellular domain of human ILT7 or a fragment comprendesu binding region to the antigen wherein the monoclonal antibody comprises amino acid sequences agree with any of the following i) to iii) as CDR1, CDR2, and CDR3 in the variable region cadenapesada and light chain variable region: i) CDR1 of a variable heavy chain region:.. SDYAWN (sec with No. of ident.:58) A CDR2 heavy chain regiónvariable: YISYSGSTSYNPSLKSR (sec with No. of ident.:59..) and CDR3 of a variable heavy chain region: SPPYYAMDY (sec with No. of ident.:60..) Variable region CDR1 light chain: KASQDVGTAVA (sec with No. of ident.:61..) CDR2 of a variable light chain region: WASTRHT (sec with No. of ident.:62..) and CDR3 of a variable light chain region: QQYSSYPLT (sec with No. of ident.:63..) ii) CDR1 of a heavy chain variable region: SYWIH (sec with No. of ident.:64).. A CDR2 heavy chain regiónvariable: RIYPGTGSTYYNEKFKG (sec with No. of ident.:65..) and CDR3 of a variable heavy chain region: YPTYDWYFDV (sec with No. of ident.:66..) CDR1 of a light chain variable region: RASQSISNYLH (sec with No. of ident.:67..) CDR2 of a variable light chain region: YASQSIS (sec with No. of ident.:68..) CDR3 of a variable light chain region: QQSNSWPLT (sec with No. of ident.:69..) iii) CDR1 of a variable heavy chain region:.. SDYAWN (sec with No. of ident.:70) Unaregión CDR2 variable heavy chain: YISYSGSTSYNPSLKSR (sec with No. of ident.:71..) CDR3 of a variable heavy chain region: ALPLPWFAY (sec with No. of ident.:72..) CDR1 of a variable light chain region: KASQDVGTAVA (sec with No. of ident.:73..) CDR2 of a variable light chain region: WASTRHT (sec with No. of ident.:74..) and CDR3 of a variable light chain region: QQYSSYPYT (sec with No. of ident.:75..).Un anticuerpo monoclonal que se une a un dominio extracelular del ILT7 humano o un fragmento que comprendesu región de unión al antígeno en donde el anticuerpo monoclonal comprende secuencias de aminoácido deacuerdo con c
