Pan Clark Qun,Sendak Rebecca,Qiu Huawei,Wei Ronnie Rong
申请号：
NZ63147314
公开号：
NZ631473A
申请日:
2014.03.13
申请国别(地区):
NZ
年份:
2017
代理人:
摘要：
Disclosed is an anti-human CD52 antibody or an antigen-binding fragment thereof, wherein said antibody comprises a heavy chain variable region and a light chain variable region, wherein said heavy chain variable region comprises: (a) the heavy chain CDR1 of SEQ ID NO: 7 (b) the heavy chain CDR2 of SEQ ID NO: 8 and (c) the heavy chain CDR3 of SEQ ID NO: 9, wherein said light chain variable region comprises (d) the light chain CDR1 of SEQ ID NO: 86, wherein residue 11 in SEQ ID NO: 86 is K, R, Q, H, S, Y, A, D, E, F, I, L, M, N, T, or V (e) the light chain CDR2 of SEQ ID NO: 34 and (f) the light chain CDR3 of SEQ ID NO: 35 (sequences as disclosed in the specification).
