NZ 599683 Disclosed is a monoclonal antibody which binds to an extracellular domain of human ILT7 or a fragment comprising its antigen binding region. The disclosed monoclonal antibody or fragment comprises the following sequences: CDR1 of a heavy chain variable region: SYWIH (SEQ ID NO: 64) CDR2 of a heavy chain variable region: RIYPGTGSTYYNEKFKG (SEQ ID NO: 65) CDR3 of a heavy chain variable region: YPTYDWYFDV (SEQ ID NO: 66) CDR1 of a light chain variable region: RASQSISNYLH (SEQ ID NO: 67) CDR2 of a light chain variable region: YASQSIS (SEQ ID NO: 68) and CDR3 of a light chain variable region: QQSNSWPLT (SEQ ID NO: 69).