An isolated antibody or antigen binding fragment thereof that binds to the polypeptide of SEQ ID NO: 9, wherein the antibody or antigen binding fragment comprises: a) a heavy chain variable domain comprising a CDR1 region comprising amino acids 31-35 of SEQ ID NO: 3, a CDR2 region comprising amino acids 50-66 of SEQ ID NO: 3, and a CDR3 region comprising amino acids 99-106 of SEQ ID NO: 3； and a light chain variable domain comprising a CDR1 region comprising amino acids 24-38 of any one of SEQ ID NO: 4, 11 or 12, a CDR2 region comprising amino acids 54-60 of any one of SEQ ID NO: 4, 11 or 12, and a CDR3 region comprising amino acids 93-101 of any one of SEQ ID NO: 4, 11 or 12； b) a heavy chain variable domain comprising a CDR1 region comprising amino acids 31-35 of SEQ ID NO: 5, a CDR2 region comprising amino acids 50-66 of SEQ ID NO: 5, and a CDR3 region comprising amino acids 99-106 of SEQ ID NO: 5； and a light chain variable domain comprising a CDR1 region comprising amino acids 24-38 of SEQ ID NO: 6, a CDR2 region comprising amino acids 54-60 of SEQ ID NO: 6, and a CDR3 region that comprises amino acids 93-101 of SEQ ID NO: 6； or c) a heavy chain variable domain comprising a CDR1 region comprising amino acids 31-35 of SEQ ID NO: 7, a CDR2 region comprising amino acids 50-66 of SEQ ID NO: 7, and a CDR3 region comprising amino acids 99-106 of SEQ ID NO: 7； and a light chain variable domain comprising a CDR1 region comprising amino acids 24-38 of SEQ ID NO: 8, a CDR2 region comprising amino acids 54-60 of SEQ ID NO: 8, and a CDR3 region that It comprises amino acids 93-101 of SEQ ID NO: 8.Un anticuerpo aislado o fragmento de unión a antígeno del mismo que se une al polipéptido de la SEQ ID NO: 9, en el que el anticuerpo o fragmento de unión a antígeno comprende: a) un dominio variable de cadena pesada que comprende una región CDR1 que comprende los aminoácidos 31-35 de la SEQ ID NO: 3, una región CDR2 que comprende los aminoácidos 50-66 de la SEQ ID NO: 3, y una re
