Muthiah Manoharan,Martin Maier,Muthusamy Jayaraman,Shigeo Matsuda,Jayaprakash K. Nair,Kallanthottathil G. Rajeev,Akin Akinc,Thomas A. Baillie
申请号：
US14661945
公开号：
US09682922B2
申请日:
2015.03.18
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to a cationic lipid having one or more biodegradable groups located in the mid- or distal section of a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.
