MANOHARAN MUTHIAH,MAIER MARTIN,JAYARAMAN MUTHUSAMY,MATSUDA SHIGEO,JAYAPRAKASH NARAYANANNAIR K,RAJEEV KALLANTHOTTATHIL G,AKINC AKIN,BAILLIE THOMAS A
申请号：
IN2586/MUMNP/2012
公开号：
IN2012MN02586A
申请日:
2012.11.20
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
The present invention relates to a cationic lipid having one or more biodegradable groups located in the mid or distal section of a lipidic moiety (e.g. a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid a lipid capable of reducing aggregation a cationic lipid of the present invention and optionally a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.
